Assessment of metabolites in urine in post-kidney transplant patients: insights into allograft function and creatinine clearance.

ABSTRACT:

Introduction

The suboptimal function of transplanted kidney can lead to imbalances in processes controlled by the kidneys, necessitating long-term monitoring of the graft's function and viability. Given the kidneys' high metabolic activity, a metabolomics approach is well-suited for tracking changes in post-transplant patients and holds significant potential for monitoring graft function.

Objectives

Examination of the response of urinary creatinine levels to (i) serum creatinine levels and (ii) allograft function during periods of impaired kidney function in post-transplant patients.

Methods

We analyzed morning and 24-h urine samples from 55 patients who underwent primary kidney transplantation and were uniformly treated with immunosuppressants, with an average follow

SUBMITTER: Baranovicova E 

PROVIDER: S-EPMC11950123 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature