Clinical management of indeterminate thyroid nodules needs to be revisited. New evidence for a personalized approach to the problem.

ABSTRACT:

Purpose

Thyroid nodules diagnosed by fine needle aspiration cytology (FNAC) as TIR3A or Class III subgroup "other types of atypia" (indeterminate thyroid nodules - ITNs), are the only ones without a unique clinical action indicated for management. This leads to multiple FNAC repetitions (FNAC-reps) and lifelong follow-up, with huge consumption of time and resources. The aims of the study were to inquire the usefulness of repeating FNAC in ITNs and perform an evaluation of a long-term follow-up of a large cohort of ITNs.

Methods

The study was conducted in two Italian high-volume tertiary centres. We selected patients who underwent the first FNAC with subsequent diagnosis of ITN in a centre involved and who then repeated it in the same institute.

Results

We included 506

SUBMITTER: Piticchio T 

PROVIDER: S-EPMC11950127 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature