Attribution of Salmonella enterica to Food Sources by Using Whole-Genome Sequencing Data.

ABSTRACT: Salmonella enterica bacteria are a leading cause of foodborne illness in the United States; however, most Salmonella illnesses are not associated with known outbreaks, and predicting the source of sporadic illnesses remains a challenge. We used a supervised random forest model to determine the most likely sources responsible for human salmonellosis cases in the United States. We trained the model by using whole-genome multilocus sequence typing data from 18,661 Salmonella isolates from collected single food sources and used feature selection to determine the subset of loci most influential for prediction. The overall out-of-bag accuracy of the trained model was 91%; the highest prediction accuracy was for chicken (97%). We applied the trained model to 6,470 isolates from humans with unknow

SUBMITTER: Rose EB 

PROVIDER: S-EPMC11950287 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature