Regulation of craving and underlying resting-state neural circuitry predict hazard of smoking lapse.

ABSTRACT: Among individuals with substance use disorders, clinical outcomes may be improved by identifying brain-behavior models that predict drug re/lapse vulnerabilities such as the ability to regulate drug cravings and inhibit drug use. In a sample of nicotine-dependent adult cigarette smokers (N = 213), this laboratory study examined associations between regulation of craving (ROC) efficacy and smoking lapse, utilized functional connectivity multivariate pattern analysis (FC-MVPA) and seed-based connectivity (SBC) analyses to identify resting-state neural circuitry underlying ROC efficacy, and then examined if the identified ROC-mediated circuitry predicted hazard of smoking lapse. Regarding behavior, worse ROC efficacy predicted a greater hazard of smoking lapse. Regarding brain and behavior, F

SUBMITTER: Upton S 

PROVIDER: S-EPMC11950297 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature