The influence of seminal microbiota on human testicular steroidogenesis: a prospective study.

ABSTRACT:

Objective

Preclinical evidence has demonstrated that gut microbiota composition can influence steroid hormone biosynthesis and spermatogenesis. This study aims to investigate the association of seminal microbiota and testicular steroidogenesis.

Patients and methods

One hundred adult eugonadal men were consecutively enrolled. The seminal concentration of Lactobacilli, anaerobic and facultative bacteria, as well as serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and total testosterone (TT) were evaluated. Unadjusted and adjusted multi-regression models were built to evaluate the relationship between seminal Lactobacilli, anaerobic and facultative bacteria, and Lactobacilli/total bacteria ratio, and serum LH, FSH, and TT. The concentrations of semi

SUBMITTER: Cannarella R 

PROVIDER: S-EPMC11950476 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature