The Effects of Semaglutide on Inflammation and Immune Activation in HIV-associated Lipohypertrophy.

ABSTRACT:

Background

Cardiovascular and metabolic comorbidities are common in people with HIV (PWH) and are linked to chronic inflammation and immune activation. We assessed the effects of semaglutide on plasma markers of immune activation/inflammation that are known to be increased in PWH and are associated with morbidity and mortality in this population.

Methods

We conducted a single-site, randomized, double-blinded, placebo-controlled trial of virologically suppressed, nondiabetic PWH ≥18 years of age on stable antiretroviral therapy with body mass index ≥ 25 kg/m², increased waist circumference/waist-to-hip ratio, and subjective increased abdominal girth after antiretroviral therapy initiation (clinicaltrials.gov: NCT04019197). Participants were randomized 1:1 to 32 wee

SUBMITTER: Funderburg NT 

PROVIDER: S-EPMC11950536 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature