Aneuploidy-driven gene expression profiling in human blastocysts: insights from RNA-Seq analysis.

ABSTRACT:

Purpose

Preimplantation aneuploidy in humans is one of the primary causes of implantation failure and embryo miscarriage. This study was conducted to gain insight into gene expression changes that may result from aneuploidy in blastocysts through RNA-Seq analysis.

Methods

The surplus embryos of preimplantation genetic testing for aneuploidy (PGT-A) candidate couples with normal karyotype and maternal age < 38 were collected following identical ovarian stimulation protocol. The embryos were selected based on trophectoderm biopsy and array comparative genomic hybridization in three groups: normal group, small chromosomes aneuploidy group (SCA), including single aneuploidy for small chromosomes 16, 20, 21, 22, and other chromosomes aneuploidy group (OCA), including single aneup

SUBMITTER: Bazrgar M 

PROVIDER: S-EPMC11950541 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature