Patient perspectives after receiving simulated preconception polygenic risk scores (PRS) for family planning.

ABSTRACT:

Purpose

The study investigates patient perspectives on the use of Preimplantation Genetic Testing for Polygenic disease (PGT-P) to select embryos with lower risks for common polygenic diseases. Participant responses and attitudes were evaluated after receiving simulated embryo PRS generated from their personal genetic profile.

Methods

Couples seeking OB/GYN or Reproductive Endocrinology and Infertility (REI) care with an interest in genetic risks for common diseases in their prospective children participated. A tool provided PRS scores for 11 conditions, using parental DNA to simulate genetic risks for hypothetical embryos produced during IVF. Participants received counseling, reviewed results online, and completed a post-test survey. Feedback from 90 participants assessed u

SUBMITTER: Katz M 

PROVIDER: S-EPMC11950577 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature