Environmental enrichment improves deficits in hippocampal neuroplasticity and cognition in prenatally aripiprazole-exposed mouse offspring.

ABSTRACT: Aripiprazole has become one of the most commonly prescribed antipsychotics, including in pregnant women, owing to a broad range of indications for psychiatric disorders and relatively few metabolic side effects. Compared with that of other antipsychotics, data regarding the safety of gestational aripiprazole exposure for offspring neurodevelopment are limited. This study investigated how prenatal exposure to aripiprazole affects the hippocampal neuroplasticity of adult offspring and whether any such effect can be reversed by environmental enrichment. Aripiprazole was administered to pregnant C57BL/6 N mice from embryonic days 6-16. Key findings revealed that aripiprazole exposure (3.0 mg/kg) persistently impaired hippocampal plasticity and related cognitive function in adult male offspring

SUBMITTER: Wang H 

PROVIDER: S-EPMC11950651 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature