In situ 3D bioprinted GDMA/Prussian blue nanozyme hydrogel with wet adhesion promotes macrophage phenotype modulation and intestinal defect repair.

ABSTRACT: Developing hydrogels with wet-adhesion, immunomodulation and regenerative repair capabilities in intestinal repair remains a formidable challenge. In the present study, the development of an anti-inflammatory, wet-adhesive, decellularized extracellular matrix hydrogel produced using three-dimensional (3D) -printing technology is presented. This hydrogel, which integrates gelatin and dopamine, was demonstrated to display excellent wet-adhesion properties, fully harnessing the outstanding regenerative potential of the decellularized small-intestine matrix. Furthermore, the integration of Prussian Blue nanozymes imparted significant anti-inflammatory and antioxidant properties. Through modulating macrophage polarization, the hydrogel was not only found to enhance tissue repair, but also to su

SUBMITTER: Su Y 

PROVIDER: S-EPMC11950758 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature