Clinical Trial: The Effects of Emulsifiers in the Food Supply on Disease Activity in Crohn's Disease: An Exploratory Double-Blinded Randomised Feeding Trial.

ABSTRACT:

Background

Advice to avoid dietary emulsifiers in Crohn's disease (CD) is based on preclinical data.

Aims

To examine the effect of diets high (HED) and low (LED) in emulsifiers in the food supply on disease activity in CD.

Methods

In a double-blinded, randomised feeding study, we randomised adults with symptomatic, sonographically active CD with ileal involvement on ≥ 2 months' stable medical therapy to 4 weeks of a HED or LED modelled on Australian healthy eating guidelines. We measured the Harvey-Bradshaw Index (HBI), sonographic indices (IBUS-SAS, bowel wall thickness), quality of life (QOL) and fatigue at baseline and study completion.

Results

We randomised 24 patients, mean age 37 (95% CI 32, 41) years, 12 male, HBI 6 (6, 8), bowel wall thickness 6.0 (5.5-

SUBMITTER: Fitzpatrick JA 

PROVIDER: S-EPMC11950802 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature