Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology.

ABSTRACT:

Background

The causes of bladder cancer are not completely understood. Our objective was to identify blood proteins and modifiable causal risk factors for bladder cancer by combining genome-wide association study (GWAS) and Mendelian randomization (MR) analyses.

Methods

We first performed a GWAS meta-analysis of 6984 bladder cancer case patients and 708 432 control individuals from 3 European databases. Next, we conducted 2-sample MR and colocalization analyses using data from the present GWAS and published GWAS meta-analyses on plasma proteins and modifiable factors.

Results

Genome-wide association study meta-analysis uncovered 17 bladder cancer susceptibility loci, of which 3 loci were novel. Genes were enriched in pathways related to the metabolic and catabolic pro

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC11950924 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature