Lactobacillus reuteri alleviates diquat induced hepatic impairment and mitochondrial dysfunction via activation of the Nrf2 antioxidant system and suppression of NF-κB inflammatory response.

ABSTRACT: Accumulating evidence has shown that elevated oxidative stress and inflammatory response leads to hepatic impairment and dysfunction of hens during the aging process. This study was conducted to investigate the potential regulatory mechanisms of Lactobacillus reuteri (L. reuteri) in alleviating hepatic oxidative stress and dysfunction induced by diquat (DQ) exposure. A total of 480 48-wk-old Jingbai hens were randomly assigned to 4 groups: control group (Con), L. reuteri group (L.R), diquat-challenged group (DQ), and L. reuteri protective group (L.R+DQ). The results demonstrated that DQ exposure induced oxidative damages and lipid metabolism disorders manifested as the elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, triglyceride (TC) contents in ser

SUBMITTER: Zhan S 

PROVIDER: S-EPMC11951011 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature