Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy.

ABSTRACT:

Purpose

Diabetic maculopathy (including diabetic macular edema [DME]) is the leading cause of vision loss in people with diabetes. We aimed to identify the genetic determinants of diabetic maculopathy.

Methods

We conducted a genome-wide association study (GWAS) in two cohorts with a meta-analysis. The Australian cohort comprised 551 cases of DME and 599 controls recruited from the states of South Australia and Tasmania. The Scottish cohort comprised 1951 cases of diabetic maculopathy and 6541 controls from the Genetics of Diabetes Audit and Research in Tayside Scotland study (GoDARTS). Genotyping, imputation, and association analysis using logistic regression were conducted in each cohort, before combining summary statistics in a meta-analysis using the GWAMA package.

Res

SUBMITTER: Gurung RL 

PROVIDER: S-EPMC11951052 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature