Prehospital tranexamic acid decreases early mortality in trauma patients: a systematic review and meta-analysis.

ABSTRACT:

Background

As an anti-fibrinolytic agent, tranexamic acid (TXA) is widely recognized for its efficacy in managing hemorrhagic conditions. Prehospital application of TXA has been reported in recent years, but its benefits in trauma patients remain debated.

Materials and methods

A literature search was conducted across databases including PubMed, Cochrane Library, Embase, Web of Science, SCOPUS, and the Cochrane Central Register for Clinical Trials from inception to October 2024, focusing on studies related to prehospital TXA and clinical outcomes in trauma patients. The Cochrane Risk of Bias 2 Tool was applied to assess the quality of randomized control trials (RCTs), while the Newcastle-Ottawa Scale was used for observational cohort studies. Data were pooled under a random-

SUBMITTER: Li Y 

PROVIDER: S-EPMC11951308 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature