Beat-to-beat analysis of hemodynamic response to mental and psychological stress in sickle cell anemia.

ABSTRACT:

Objectives

Vaso-occlusive crises (VOCs) are a hallmark symptom of sickle cell disease (SCD). Physical stressors can trigger decreased microvascular blood flow and increase the risk for VOCs. However, the effect of mental and psychological stressors on vascular physiology in SCD is not well-established. We hereby examined fluctuations in continuous blood pressure (BP) to evaluate hemodynamic changes in SCD patients during mental and psychological stress.

Methods

Thirteen SCD (HbSS) subjects from the Children's Hospital Los Angeles and 11 healthy (HbAA) volunteers were recruited. Continuous BP was recorded as subjects participated in two mental and one psychological stress tasks. Systolic beat-to-beat BP variability (BPV) measurements were calculated for each subject. Three ve

SUBMITTER: Abiri A 

PROVIDER: S-EPMC11951424 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature