Characterizing the Prevalence of Psychiatric Conditions and Fear-Potentiated Startle Response in Civilians with a History of Trauma and Seizures.

ABSTRACT:

Background

Depression, posttraumatic stress disorder (PTSD), and suicidality are more prevalent among people with seizures, but few studies exist in low-resourced minoritized populations. Existing knowledge of the overlapping neurocircuitry between seizure activity in limbic regions (eg, medial temporal lobe epilepsy) and PTSD also suggests that people with seizure histories may exhibit PTSD-like alterations in their fear-potentiated startle (FPS) responses. However, this hypothesis has yet to be systematically tested. Here, we leveraged a large study on stress and trauma to evaluate the prevalence of psychiatric conditions and FPS responses in a low-resourced minoritized population of individuals with a history of seizures.

Methods

Prevalence of self-reported PTSD symptoms,

SUBMITTER: Prochaska T 

PROVIDER: S-EPMC11951433 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature