CDON contributes to Hedgehog-dependent patterning and growth of the developing limb.

ABSTRACT: Hedgehog (HH) signaling is a major driver of tissue patterning during embryonic development through the regulation of a multitude of cell behaviors including cell fate specification, proliferation, migration, and survival. HH ligands signal through the canonical receptor PTCH1 and three co-receptors, GAS1, CDON and BOC. While previous studies demonstrated an overlapping and collective requirement for these co-receptors in early HH-dependent processes, the early embryonic lethality of Gas1;Cdon;Boc mutants precluded an assessment of their collective contribution to later HH-dependent signaling events. Specifically, a collective role for these co-receptors during limb development has yet to be explored. Here, we investigate the combined contribution of these co-receptors to digit specificati

SUBMITTER: Echevarria-Andino ML 

PROVIDER: S-EPMC11951443 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature