Adjacent spillover efficacy of Wolbachia for control of dengue: emulation of a cluster randomised target trial.

ABSTRACT:

Background

Matings between male Aedes aegypti mosquitoes infected with wAlbB strain of Wolbachia and wild-type females yield non-viable eggs, thereby suppressing Ae. aegypti abundance in the field. We evaluated the spillover efficacy of releasing wAlbB-infected Ae. aegypti male mosquitoes to suppress dengue in sites adjacent to release sites (spillover sites).

Methods

The protocol of a two-arm cluster-randomised test-negative controlled trial (cRCT) was specified and emulated using a nationally representative dengue test-negative/positive database of 454,437 individuals reporting for febrile illness to primary or secondary care in public healthcare institutions. Spillover intervention sites were defined by geolocating locations which were adjacent to, i.e. shared geographica

SUBMITTER: Lim JT 

PROVIDER: S-EPMC11951538 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature