Distinct 5-methylcytosine profiles of LncRNA in breast cancer brain metastasis.

ABSTRACT:

Background

Recent studies have identified a complex relationship between methylation patterns and the development of various cancers. Breast cancer (BC) is the second leading cause of cancer mortality among women. Approximately 5-20% of BC patients are at risk of BC brain metastases (BCBM). Although 5-methylcytosine (m5C) has been identified as an important regulatory modifier, its distribution in BCBM is not well understood. This study aimed to investigate the distribution of m5C in BCBM.

Materials and methods

Samples from BCBM (231-BR cells) and BC (MDA-MB-231 cells) groups were subjected to a comprehensive analysis of the m5C methylation in long non-coding RNA (lncRNA) using methylated RNA immunoprecipitation next-generation sequencing (MeRIP-seq). The expression levels o

SUBMITTER: Wang S 

PROVIDER: S-EPMC11951547 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature