HTAS2R38 polymorphisms modulate oral microbiota and influence the prevalence and treatment outcome of halitosis.

ABSTRACT:

Background

The genetic susceptibility of halitosis is unclear, challenging its precise management in high-risk population. Here we investigated the association of hTAS2R38 polymorphisms with the prevalence and treatment outcome of halitosis, with a particular focus on oral microbiota.

Methods

A cross-sectional study including 689 participants was conducted to investigate the association between hTAS2R38 polymorphisms and halitosis. A 6-month cohort including 60 halitosis patients was established to explore the relationship between hTAS2R38 polymorphisms and treatment outcome of halitosis. Salivary microbiota was further analyzed and its correlation with hTAS2R38 polymorphisms was investigated.

Results

In the cross-sectional study, a higher prevalence of halitosis was

SUBMITTER: Mei H 

PROVIDER: S-EPMC11951550 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature