A narrative review of glucagon-like peptide-1 receptor agonists prior to deep sedation or general anesthesia.

ABSTRACT: Glucagon-like peptide-1 receptor agonists are a class of drugs that mimic a natural incretin hormone released by the intestine after meals, and they are well-suited for treating type 2 diabetes. Glucagon-like peptide-1 receptor agonists also lead to satiety and appetite reduction through action on the brain's appetite regulation centers, leading to weight loss in obese patients. However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period. The purpose of this review is (i) to explore the present knowledge about the risk of aspiration b

SUBMITTER: Vetrugno L 

PROVIDER: S-EPMC11951578 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature