Idiopathic epilepsy in dogs is associated with dysbiotic faecal microbiota.

ABSTRACT:

Background

The gut microbiota plays a crucial role in modulating various physiological and pathological processes through its metabolites, including short-chain fatty acids (SCFA), which impact immune system development, gastrointestinal health, and brain functions via the gut-brain axis. Dysbiosis, an imbalance in gut microbiota composition, has been linked to neuroinflammatory and neurodegenerative conditions, including epilepsy. In dogs, idiopathic epilepsy has been hypothesized to be influenced by gut microbiota composition, although studies on this association are limited and show inconsistent results. Here, we compared the faecal microbiota of idiopathic epileptic drug-naïve dogs and healthy controls. To this aim, we recruited 19 idiopathic epileptic dogs and 17 healthy contr

SUBMITTER: Silvestrino M 

PROVIDER: S-EPMC11951594 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature