Pulmonary function testing in pediatric allogeneic stem cell transplant recipients to monitor for Bronchiolitis obliterans syndrome: a systematic review.

ABSTRACT:

Background

Bronchiolitis obliterans syndrome (BOS) represents a significant source of morbidity and non-relapse mortality among children and young adults treated with allogeneic hematopoietic stem cell transplantation (aHSCT). Pulmonary function testing (PFT) pre- and post-aHSCT may allow for pre-symptomatic detection of BOS, and thus early intervention. Current guidelines and practices vary regarding which tests to perform and timing relative to transplant. A systematic review evaluating PFT before and after pediatric aHSCT was conducted to inform American Thoracic Society clinical practice guidelines on detection of BOS.

Objective

To determine the optimal approach to conducting PFT prior to and after pediatric aHSCT.

Study design

We performed a systematic review of

SUBMITTER: Gower WA 

PROVIDER: S-EPMC11951628 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature