A scoring model based on the pleural effusion adenosine deaminase-to-serum C-reactive protein ratio for differentiating tuberculous pleural effusion from non-tuberculous benign pleural effusion.

ABSTRACT:

Background

Differentiating tuberculous pleural effusion (TPE) from non-tuberculous benign pleural effusion (non-TB BPE) can be challenging, especially in patients with low levels of pleural effusion adenosine deaminase (pADA) and negative etiological evidence. This study aimed to evaluate the diagnostic performance of the pADA to serum C-reactive protein ratio (pADA/sCRP) and to develop a scoring model for diagnosing TPE.

Methods

This retrospective study included 364 patients with pleural effusion, comprising 121 with TPE and 243 with non-TB BPE from Peking Union Medical College Hospital. Clinical, laboratory, and imaging data were collected, and comparisons were made between the two groups. The diagnostic performance of the pADA/sCRP ratio and other statistically significan

SUBMITTER: Hou H 

PROVIDER: S-EPMC11951641 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature