Biological characteristics and transcriptomic profile of adipose-derived mesenchymal stem cells isolated from prion-infected murine model.

ABSTRACT:

Background

Prion diseases are characterized by accumulation of misfolded host prion proteins (PrP^Sc) that produce aggregates in brain tissue. Mesenchymal stem cells (MSCs) have been identified as potential therapeutic candidates for prion diseases. However, it has been demonstrated that MSCs maintained and expressed PrP^Sc levels following inoculation, raising concerns regarding their safe and effective use in medical applications. Prion infectivity has been reported in fat tissues, thus the response of adipose-derived MSCs (AdMSCs) to prion infection needs to be fully studied.

Methods

For this study, we analyzed the properties of AdMSCs isolated from mice infected with the ME7 scrapie strain and compared them with negative controls. We investigated morp

SUBMITTER: Zayed M 

PROVIDER: S-EPMC11951670 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature