Plasma perfluoroalkyl substances and breast cancer risk in Brazilian women: a case-control study.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants, and have been detected in human blood. Although PFAS may increase the risk of breast cancer in humans, findings from previous epidemiological studies on the link between PFAS and breast cancer are controversial. Additionally, most studies of PFAS to date did not distinguish between isomers. Here, we examined the association of PFAS exposure and breast cancer risk in Brazilian women, who represent a racially and ethnically diverse group.

Methods

We conducted a case-control study of 471 women with breast cancer and 471 matched controls attending hospitals in São Paulo, Brazil from 2001 to 2006. Plasma concentrations of PFAS congeners were measured using in-port arylation gas chromato

SUBMITTER: Itoh H 

PROVIDER: S-EPMC11951677 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature