Distinct risks of exacerbation and lung function decline between never-smokers and ever-smokers with COPD.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) can occur in patients without a history of smoking, which is a strong risk factor for COPD. However, few studies have focused on the prognosis of never-smokers with COPD. We investigated the difference of the longitudinal clinical outcomes between never-smokers and ever-smokers with COPD.

Methods

We retrospectively analyzed patients with COPD who underwent chest computed tomography and longitudinal lung function tests from January 2013 to December 2020. We classified patients according to smoking status and examined their histories of acute exacerbation and long-term changes in lung function.

Results

Among 583 patients with COPD, 75 (12.9%) had no smoking history. These never-smokers with COPD were predominantly

SUBMITTER: Park H 

PROVIDER: S-EPMC11951795 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature