The use of oxymetazoline-based nasal solutions to remove bacteria-blood debris and eradicate Rothia dentocariosa: an artificial cavity model study.

ABSTRACT:

Background

This study evaluated the antibacterial properties of a potential pulpal medicament, a nasal solution with oxymetazoline (NS-OXY, 0.05%), against a dentinal caries pathogen.

Methods

Using a disc diffusion susceptibility test (n = 6), Rothia dentocariosa was grown on brain-heart infusion (BHI) agar plates and exposed to OXY (0.05%), benzalkonium chloride (BKC-0.025%), OXY-NS (with OXY-0.05% and BKC), ferric sulfate (20%; ViscoStat), and distilled water (DI). This was followed by exposure of an artificial dental caries model with sheep blood to simulate the clinical pulpotomy procedure. An antibacterial broth inhibition test was conducted by adding the test samples in BHI broth at 37 ± 0.5 °C in an aerobic chamber.

Results

In the disc diffusion test, NS-OXY an

SUBMITTER: Kumar D 

PROVIDER: S-EPMC11951828 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature