IMGN853 Induces Autophagic Cell Death in Combination Therapy for Ovarian Cancer.

ABSTRACT:

Abstract

Antibodies targeting folate receptor 1 (FOLR1) induce autophagic cell death in addition to antibody-dependent cytotoxicity, but the biological relevance of anti-FOLR1 antibody–induced autophagy for clinical applications remains unclear. In this study, we investigated the role of autophagic cell death triggered by IMGN853 (mirvetuximab soravtansine), an FOLR1-targeted antibody–drug conjugate, and explored potential combinations of IMGN853 with chemotherapeutic drugs used for ovarian cancer treatment. We discovered that FOLR1 was predominantly expressed in epithelial ovarian cancer cells, with similar expression levels observed in both primary ovarian tumors and metastatic omental tumors from patients with high-grade serous ovarian cancer (HGSC). Treatment with IMGN853 impro

SUBMITTER: Chelariu-Raicu A 

PROVIDER: S-EPMC11951858 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature