Steroid hormone levels vary with sex, aging, lifestyle, and genetics.

ABSTRACT: Steroid hormone levels vary greatly among individuals, between sexes, with age, and across health and disease. What drives variance in steroid hormones and how they vary in individuals over time are not well studied. To address these questions, we measured 17 steroid hormones in a sex-balanced cohort of 949 healthy donors aged 20 to 69 years. We investigated associations between steroid levels and biological sex, age, clinical and demographic data, genetics, and plasma proteomics. Steroid hormone levels were strongly affected by sex and age, and a high number of lifestyle habits. Key observations were the broad impact of hormonal birth control in female donors and the relationship with smoking in male donors. In a 10-year follow-up study, we identified significant associations between ster

SUBMITTER: Deltourbe LG 

PROVIDER: S-EPMC11952096 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature