Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.

ABSTRACT: Tendon impingement upon bone generates a multiaxial mechanical strain environment with markedly elevated transverse compressive strain, which elicits a localized fibrocartilage phenotype characterized by accumulation of glycosaminoglycan (GAG)-rich matrix and remodeling of the collagen network. While fibrocartilage is a normal feature in impinged regions of healthy tendons, excess GAG deposition and disorganization of the collagen network are hallmark features of tendinopathy. Accordingly, impingement is clinically recognized as an important extrinsic factor in the initiation and progression of tendinopathy. Nevertheless, the mechanobiology underlying tendon impingement remains understudied. Prior efforts to elucidate the cellular response to tendon impingement have applied uniaxial compre

SUBMITTER: Wise BC 

PROVIDER: S-EPMC11952120 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature