Activatable near-infrared fluorescence and chemical exchange saturation transfer MRI multimodal imaging probe for tumor detection in vitro and in vivo.

ABSTRACT: Multimodal imaging has emerged as a powerful tool in biomedical research and clinical diagnostics. Ideally, it combines multiple imaging techniques to provide complementary anatomical and molecular information in living subjects. Particularly desirable are multimodal imaging probes capable of providing differential diagnostic signals upon interaction with specific molecular targets. Hydrogen peroxide (H₂O₂) is a key target in this regard, since it is typically overexpressed in cancer cells. In this study, we present a small-molecule probe that not only selectively detects endogenous H₂O₂ through multimodal imaging, with a significant H₂O₂-triggered 15-fold fluorescence enhancement but also turns "on" a chemical exchange satu

SUBMITTER: Karan S 

PROVIDER: S-EPMC11952121 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature