TsRNA-49-73-Glu-CTC: A promising serum biomarker in non-small cell lung cancer.

ABSTRACT:

Objective

Lung cancer has the highest incidence and mortality rates globally, with the majority of cases classified as non-small cell lung cancer (NSCLC). Due to the absence of specific tumor biomarkers, most lung cancer cases are diagnosed at an advanced stage. Therefore, the identification of novel molecular biomarkers with high sensitivity and specificity for early diagnosis is deemed crucial for enhancing the treatment of NSCLC. Transfer RNA-derived small RNA (tsRNA) is closely associated with malignant tumors and holds promise as a potential biomarker for tumor diagnosis. This study aimed to investigate whether serum tsRNA could serve as a biomarker for NSCLC.

Methods

Differentially expressed tsRNAs were identified through high-throughput sequencing of serum samples obt

SUBMITTER: Li C 

PROVIDER: S-EPMC11952254 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature