Unveiling amyotrophic lateral sclerosis complexity: insights from proteomics, metabolomics and microbiomics.

ABSTRACT: Amyotrophic lateral sclerosis is the most common motor neuron disease and manifests as a clinically and genetically heterogeneous neurodegenerative disorder mainly affecting the motor systems. To date, despite promising results and accumulating knowledge on the pathomechanisms of amyotrophic lateral sclerosis, a specific disease-modifying treatment is still not available. In vitro and in vivo disease models coupled with multiomics techniques have helped elucidate the pathomechanisms underlying this disease. In particular, omics approaches are powerful tools for identifying new potential disease biomarkers that may be particularly useful for diagnosis, prognosis and assessment of treatment response. In turn, these findings could support physicians in stratifying patients into

SUBMITTER: Scarcella S 

PROVIDER: S-EPMC11952287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature