Inverted Alu repeats in loop-out exon skipping across hominoid evolution.

ABSTRACT:

Background

Changes in RNA splicing over the course of evolution have profoundly diversified the functional landscape of the human genome. While DNA sequences proximal to intron-exon junctions are known to be critical for RNA splicing, the impact of distal intronic sequences remains underexplored. Emerging evidence suggests that inverted pairs of intronic Alu elements can promote exon skipping by forming RNA stem-loop structures. However, their prevalence and influence throughout evolution remain unknown.

Results

Here, we present a systematic analysis of inverted Alu pairs across the human genome to assess their impact on exon skipping through predicted RNA stem-loop formation and their relevance to hominoid evolution. We found that inverted Alu pairs, particularly pairs of A

SUBMITTER: Denisko D 

PROVIDER: S-EPMC11952303 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature