IAN: An Intelligent System for Omics Data Analysis and Discovery.

ABSTRACT: IAN is an R package that addresses the challenge of integrating, analyzing and interpreting high-throughput "omics" data, using a multi-agent artificial intelligence (AI) system. IAN leverages popular pathway and regulatory datasets (KEGG, WikiPathways, Reactome, GO, ChEA) and the STRING database for protein-protein interactions to perform standard enrichment analysis. The individual enrichment results are then used to generate insightful summaries, for each of the datasets, using a large language model (LLM) through a multi-agent architecture. These summaries are then contextually integrated and interpreted by the LLM, guided by carefully engineered prompts and grounding instructions, to provide insightful explanations, system overview, key regulators, novel observations etc. We demonstra

SUBMITTER: Nagarajan V 

PROVIDER: S-EPMC11952324 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature