Sub-Second Fluctuation between Top-Down and Bottom-Up Modes Distinguishes Diverse Human Brain States.

ABSTRACT: Information continuously flows between regions of the human brain, exhibiting distinct patterns that dynamically shift across states of consciousness, cognitive modes, and neuropsychiatric conditions. In this study, we introduce Relative Phase Analysis (RPA), a method that leverages phase-lead/lag relationships to reveal the real-time dynamics of dominant directional patterns and their rapid transitions. We demonstrate that the human brain switches on a sub-second timescale between a top-down mode-where anterior regions drive posterior activity-and a bottom-up mode, characterized by reverse directionality. These dynamics are most pronounced during full consciousness and gradually become less distinct as awareness diminishes. Furthermore, we find from simultaneous EEG-fMRI recordings that t

SUBMITTER: Park Y 

PROVIDER: S-EPMC11952419 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature