CREB-family transcription factors and vasopressin-mediated regulation of <i>Aqp2</i> gene transcription.

ABSTRACT:

Background

Water homeostasis is regulated by the peptide hormone arginine vasopressin (AVP), which promotes water reabsorption in the renal collecting duct. The regulation of Aqp2 gene transcription is a key mechanism through which AVP modulates water transport as disruption of this mechanism leads to water balance disorders. Therefore, an important goal is to understand the regulatory processes that control Aqp2 gene transcription. While CREB (CREB1) has been proposed as the primary transcription factor responsible for Aqp2 transcription, recent evidence challenges this view, suggesting that other CREB-like transcription factors, including ATF1 and CREM, may play a role.

Methods

We employed the CRISPR/Cas9 gene-editing system to delete Atf1, C

SUBMITTER: Murillo-de-Ozores AR 

PROVIDER: S-EPMC11952463 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature