Microtubule-dependent cell polarity regulates skin-resident macrophage phagocytosis and directed cell migration.

ABSTRACT: Immune cells rapidly respond to tissue damage through dynamic properties of the cytoskeleton. How microtubules control immune cell functions during injury responses remains poorly understood. Within skin, tissue-resident macrophages known as Langerhans cells use dynamic dendrites to surveil the epidermis for damage and migrate through a densely packed epithelium to wounds. Here, we use Langerhans cells within the adult zebrafish epidermis as a model to investigate roles for microtubules in immune cell tissue surveillance, phagocytosis, and directed migration. We describe microtubule organization within Langerhans cells, and show that depolymerizing the microtubule cytoskeleton alters dendrite morphology, debris engulfment, and migration efficiency. We find that the microtubule organizing c

SUBMITTER: Peterman E 

PROVIDER: S-EPMC11952491 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature