Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA.

ABSTRACT: The use of assisted reproductive technologies (ART) has enabled the birth of over 9 million babies; but it is associated with increased risks of negative metabolic outcomes in offspring. Yet, the underlying mechanism remains unknown. Calcium (Ca²⁺) signals, which initiate embryo development at fertilization, are frequently disrupted in human ART. In mice, abnormal Ca²⁺ signals at fertilization impair embryo development and adult offspring metabolism. Changes in intracellular Ca²⁺ drive mitochondrial activity and production of metabolites used by the epigenetic machinery. For example, acetyl-CoA (derived mainly from pyruvate) and lactyl-CoA (derived from lactate) are used for writing H3K27ac and H3K18la marks that orchestrate initiation of development. Using

SUBMITTER: Savy V 

PROVIDER: S-EPMC11952514 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature