The association between undetected heteroresistance and antibiotic treatment failure in complicated urinary tract infection.

ABSTRACT:

Background

Antibiotic resistance is a worsening public health threat. One poorly understood aspect of this problem is unexpected antibiotic treatment failure; when an infecting isolate is deemed susceptible to a given antibiotic, yet treatment with that drug fails. It has been proposed that heteroresistance may be an explanation for at least some unexplained treatment failures. Heteroresistance occurs when a bacterial isolate harbors a minor subpopulation of resistant cells which coexists with a majority susceptible population. The clinical relevance of heteroresistance is not clear.

Methods

We obtained 291 index isolates from 288 unique patients in the piperacillin/tazobactam arm of the ALLIUM phase 3 clinical trial for the treatment of Gram-negative pathogens causing compl

SUBMITTER: Abbott CN 

PROVIDER: S-EPMC11952596 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature