Childhood adversity is associated with longitudinal white matter changes after adulthood trauma.

ABSTRACT:

Background

Childhood adversity is associated with susceptibility to posttraumatic stress disorder (PTSD) in adulthood. Both PTSD and adverse experiences in childhood are linked to disrupted white matter microstructure, yet the role of white matter as a potential neural mechanism connecting childhood adversity to PTSD remains unclear. The present study investigated the potential moderating role of previous childhood adversity on longitudinal changes in white matter microstructures and posttraumatic stress symptoms following a recent traumatic event in adulthood.

Methods

As part of the AURORA Study, 114 recent trauma survivors completed diffusion weighted imaging at 2-weeks and 6-months after exposure. Participants reported on prior childhood adversity and PTSD symptoms at 2-w

SUBMITTER: Tianyi L 

PROVIDER: S-EPMC11952606 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature