A Quantitative Trait Locus for Reduced Microglial <i>APOE</i> Expression Associates with Reduced Cerebral Amyloid Angiopathy.

ABSTRACT: The Apolipoprotein E (APOE) e4 and e2 alleles are respectively the most risk increasing and risk decreasing, common genetic risk factors for Alzheimer's disease (AD)^1,2. They strongly affect Aβ burden in the brain parenchyma¹, a core hallmark of AD, but also at the level of the brain vasculature, i.e. cerebral amyloid angiopathy (CAA)^1,3, which in turn relates to increased risk for amyloid-related imaging abnormalities (ARIA) in APOE*4 carriers when receiving anti-Aβ antibody treatments⁴. This makes APOE a highly pursued AD drug target. A crucial question in the field is whether it would be beneficial to either increase or decrease APOE (particularly APOE*4) levels⁵. The answer from rodent work appear

SUBMITTER: Belloy ME 

PROVIDER: S-EPMC11952609 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature