Association of Polygenic Risk for Psychiatric Disorders with Cardiometabolic Disease.

ABSTRACT:

Importance

Clinical diagnoses of psychiatric disorders are associated with cardiometabolic diseases (CMDs) such as type 2 diabetes and ischemic heart diseases. Studying how genetic liability for psychiatric disorders relate to CMD risk will offer novel insight into the relationship between psychiatric disorders and CMDs.

Objective

To evaluate the associations between psychiatric polygenic risk scores (PRSs) and clinically diagnosed CMDs while accounting for cross-disorder pleiotropy.

Design setting and participants

This study computed PRSs for attention deficit-hyperactivity disorder (ADHD), major depressive disorder (MDD), anxiety disorder, post-traumatic stress disorder (PTSD), bipolar disorder, and schizophrenia. The analysis was conducted in three population-based

SUBMITTER: Bergstedt J 

PROVIDER: S-EPMC11952624 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature