Foundry-fabricated dual-color nanophotonic neural probes for photostimulation and electrophysiological recording.

ABSTRACT:

Significance

Compact tools capable of delivering multicolor optogenetic stimulation to deep tissue targets with sufficient span, spatiotemporal resolution, and optical power remain challenging to realize. Here, we demonstrate foundry-fabricated nanophotonic neural probes for blue and red photostimulation and electrophysiological recording, which use a combination of spatial multiplexing and on-shank wavelength demultiplexing to increase the number of on-shank emitters.

Aim

We demonstrate silicon (Si) photonic neural probes with 26 photonic channels and 26 recording sites, which were fabricated on 200-mm diameter wafers at a commercial Si photonics foundry. Each photonic channel consists of an on-shank demultiplexer and separate grating coupler emitters for blue and red light

SUBMITTER: Roszko DA 

PROVIDER: S-EPMC11952718 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature