Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal-fetal interface.

ABSTRACT: Preeclampsia (PE), a major cause of maternal and perinatal mortality with highly heterogeneous causes and symptoms, is usually complicated by gestational diabetes mellitus (GDM). However, a comprehensive understanding of the immune microenvironment in the placenta of PE and the differences between PE and GDM is still lacking. In this study, cytometry by time of flight indicated that the frequencies of memory-like Th17 cells (CD45RA^-CCR7⁺IL-17A⁺CD4⁺), memory-like CD8⁺ T cells (CD38⁺CXCR3^-CCR7⁺Helios^-CD127^-CD8⁺) and pro-inflam Macs (CD206^-CD163^-CD38^midCD107a^lowCD86^midHLA-DR^midCD14⁺) were increased

SUBMITTER: Fei H 

PROVIDER: S-EPMC11952753 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature