A framework and analytical exploration for a data-driven update of the Sequential Organ Failure Assessment (SOFA) score in sepsis.

ABSTRACT:

Objective

The Sepsis-3 consensus statement emphasised the need for data-based approaches to organ failure assessment and use the Sequential Organ Failure Assessment (SOFA) for this purpose. We aimed to develop a framework for a data-driven update to the SOFA score for patients with sepsis.

Design

Systematic analysis of potential markers of organ dysfunction in a retrospective, observational study.

Setting

Intensive care units from three tertiary hospital centres in the United States, the Netherlands, and Austria were included in the study.

Participants

28 100 American, 5339 Dutch, and 2450 Austrian patients with suspected sepsis were included in this study.

Measurements and main results

We assessed 56 organ function variables. We applied area under curve

SUBMITTER: Plecko D 

PROVIDER: S-EPMC11952785 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature