HIV-1 Tat protein alters medial prefrontal cortex neuronal activity and recognition memory.

ABSTRACT: Despite advancements in combined antiretroviral therapy, human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) continue to affect 40%-50% of people living with HIV. While neuroimaging studies have revealed HIV-1-induced alterations in cortical networks and brain macrostructures, it still remains unclear how individual neurons in the medial prefrontal cortex (mPFC) are affected during recognition memory. Using in vivo calcium imaging in an HIV-1 transactivator of transcription (Tat) transgenic mouse model, we examined mPFC neuronal activity during a novel object recognition memory task. Our findings show that HIV Tat expression reduces overall neuronal activity in Tat(+) mice without altering the number of activated cells. Moreover, distinct neuronal subpopulat

SUBMITTER: Yadav-Samudrala BJ 

PROVIDER: S-EPMC11952812 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature