Investigation of the stemness and wound-healing potential of long-term cryopreserved stromal vascular fraction cells.

ABSTRACT:

Introduction

Stromal vascular fraction (SVF), a heterogeneous cell population primarily derived from adipose tissue, is widely utilized in regenerative therapies for its wound-healing properties and accessibility. While its immediate availability is advantageous, repeated harvesting can be burdensome, especially for elderly patients, and the regenerative capacity of SVF declines with donor age. Long-term cryopreservation offers a potential solution by allowing the banking of SVF from younger donors for future use; however, the impact of this process on SVF functionality remains elusive. This study investigates the stemness and wound-healing potential of SVF following prolonged cryopreservation.

Methods

SVF cells were isolated from adipose tissue harvested from twelve patient

SUBMITTER: Inafuku N 

PROVIDER: S-EPMC11952815 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature